Indinavir and atazanavir; comparison of predicted property by chemoinformatics technique and implication on renal problem in HIV infected patients

Introduction HIV infection becomes the present problematic infectious disease worldwide. The pathogenic HIV virus will destroy immune system of the patients and result in several clinical problems. Anti-HIV medication is the standard treatment for the HIV infected patient. An important concern of anti-HIV drugs use is the possible adverse effects (1). The kidney problems due to anti-HIV is widely mentioned. Indinavir and atazanavir are the two drugs with many reports on renal toxicity (2). Focusing on the pathogenesis, the crystal formation is believed to be the important pathological process. Here, the authors use the standard chemoinformatics technique for predicting properties of both drug and compare the derived result.